immunotherapy
Formate is a short-chain, one-carbon organic acid and a key product of microbial one-carbon (1C) metabolism, produced by gut bacteria via the enzyme pyruvate formate lyase (pfl).
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Source papers
- Exercise-Induced Microbiota Metabolite Enhances CD8 T Cell Antitumor Immunity Promoting Immunotherapy Efficacy doi:10.1016/j.cell.2025.06.018