One-Carbon (1C) Metabolism

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immunotherapy

One-carbon (1C) metabolism is the set of folate-dependent and folate-independent biochemical pathways that transfer single-carbon units, supporting nucleotide synthesis, methylation reactions, and — in bacteria — the production of formate.

Source papers

  • Exercise-Induced Microbiota Metabolite Enhances CD8 T Cell Antitumor Immunity Promoting Immunotherapy Efficacy Catherine M. Phelps, Nathaniel B. Willis, Tingting Duan, et al., Giorgio Trinchieri, Marlies Meisel · 2025 doi:10.1016/j.cell.2025.06.018