Today's Paper · 2026.07.20
Stromal-Derived IL-8 Promotes M2 Macrophage Polarization via the RhoA/MRTF-A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer
DESMIN+ 암연관섬유아세포가 분비하는 IL-8이 CXCR2-RhoA-MRTF-A-SRF 경로로 대식세포를 M2형으로 유도해 CD8 T세포를 억제하며, CXCR2 차단이 이를 되돌린다.
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