Fecal Microbiota Transplantation (FMT)

Back to Wiki

immunotherapy

Fecal microbiota transplantation (FMT) is the transfer of donor fecal microbiota into antibiotic-pretreated recipient mice (or, in translational studies, from human donors into mice) to test whether a donor’s microbiome phenotype causally drives a physiological effect.

Source papers

  • Exercise-Induced Microbiota Metabolite Enhances CD8 T Cell Antitumor Immunity Promoting Immunotherapy Efficacy Catherine M. Phelps, Nathaniel B. Willis, Tingting Duan, et al., Giorgio Trinchieri, Marlies Meisel · 2025 doi:10.1016/j.cell.2025.06.018