Stress Granules (SGs)

Stress granules (SGs) are dynamic, non-membranous cytoplasmic condensates that cells assemble in response to stress conditions such as oxidative stress, nutrient deprivation, or chemoradiotherapy. Built around scaffolding proteins like G3BP1, stress granules transiently sequester specific RNAs and proteins, pausing their normal activity until the stress subsides and the granules disassemble. Because they can concentrate proteins involved in cell-death pathways, stress granules are increasingly recognized as a stress-adaptive mechanism that cancer cells can co-opt to survive therapy-induced stress.