tumor-microenvironment
Serum response factor (SRF) is a transcription factor that binds CArG-box DNA elements in target gene promoters. Together with co-activators such as MRTF-A, SRF drives expression of genes involved in cytoskeletal dynamics and cell phenotype programs.
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Source papers
- Stromal-Derived IL-8 Promotes M2 Macrophage Polarization via the RhoA/MRTF-A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer doi:10.1002/advs.202508001