tumor-microenvironment
The Hippo pathway is a signaling axis in which ECM detachment normally activates Lats1/2 kinases to inactivate the transcriptional co-activators YAP and TAZ, driving anoikis.
In cancer, this axis is frequently deregulated so that YAP/TAZ remain active after detachment, blocking anoikis; experimentally, knocking down YAP/TAZ restores anoikis sensitivity in these cells.
Related terms
Source papers
- Anoikis: To Die or Not to Die? doi:10.3390/ijms27020579