Trogoptosis

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tumor-microenvironment

Trogoptosis is trogocytosis-mediated cell death of the donor cell, caused by substantial loss of its own plasma membrane during the membrane-transfer process. It is distinct from fratricide, which kills the antigen-dressed recipient cell instead.

One example is FcγR- and CD11b/CD18-mediated trogoptosis of antibody-opsonized tumor cells by neutrophils/macrophages, which is enhanced by blocking the CD47 “don’t eat me” signal.

Related terms

Source papers

  • Trogocytosis-mediated immune evasion in the tumor microenvironment Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred L. M. Bothwell, Jae Hun Shin · 2025 doi:10.1038/s12276-024-01364-2